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Article

Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model

23 Jun 2011

Abstract excerpt

OBJECTIVE: Parathyroid hormone-related protein (PTHrP) regulates the rate of differentiation of growth chondrocytes and is also expressed in articular chondrocytes. This study tested the hypothesis that PTHrP might have a regulatory role in articular chondrocyte maintenance. METHODS: Control sequences of growth differentiation factor 5 were used to delete PTHrP from articular chondrocytes in the mid-region of...

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PMID: 21702022
DOI: 10.1002/art.30515

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