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Article

Induction of frameshift mutations in cultured mammalian cells within a transfected sequence containing a poly(dC-dA).poly(dT-dG) microsatellite.

Environmental and molecular mutagenesis - 1 Jan 1996

Riedinger K L, Hanford M G, Farber R A

Abstract excerpt

A cultured mouse cell line with an integrated copy of a plasmid that contains a short dinucleotide repeat sequence (microsatellite) has been used to determine the frequencies and types of mutation induced by two frameshift mutagens. The presence of the microsatellite, which consists of 17 repeats of a poly(dC-dA).poly(dT-dG) sequence, disrupts the reading frame of a gene coding for neomycin resistance. Revertants...

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PMID: 8908187
DOI: 10.1002/(SICI)1098-2280(1996)28:3<276::AID-EM12>3.0.CO;2-C

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