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Article

Induction of microsatellite instability by oxidative DNA damage

13 Oct 1998

Abstract excerpt

Instability of repetitive sequences, both in intronic sequences and within coding regions, has been demonstrated to be a hallmark of genomic instability in human cancer. Understanding how these mutational events arise may provide an opportunity for prevention or early intervention in cancer development. To study the source of this instability, we have identified a region of the beta-lactamase gene that is...

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PMID: 9770509
DOI: 10.1073/pnas.95.21.12468

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