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Article

The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.

The Journal of biological chemistry - 14 Jan 2005

Wojciechowska Marzena, Bacolla Albino, Larson Jacquelynn E, Wells Robert D

Abstract excerpt

The capacity of (CTG.CAG)n and (GAA.TTC)n repeat tracts in plasmids to induce mutations in DNA flanking regions was evaluated in Escherichia coli. Long repeats of these sequences are involved in the etiology of myotonic dystrophy type 1 and Friedreich's ataxia, respectively. Long (CTG.CAG)n (where n = 98 and 175) caused the deletion of most, or all, of the repeats and the flanking GFP gene. Deletions of 0.6-1.8...

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Source

Identifiers

PMID: 15489504
DOI: 10.1074/jbc.M410427200

Genes

GAA
DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.PMID 15489504Read ↗

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