Article
Gene expression in the limbless mutant: polarized gene expression in the absence of Shh and an AER.
Developmental biology - 1 Nov 1996
Noramly S, Pisenti J, Abbott U, Morgan B
Abstract excerpt
Limb buds in the limbless chick begin to form normally but fail to form an AER and ultimately degenerate. Wnt7a and LMX-1, which are restricted to the dorsal half of a normal limb bud, are expressed throughout the ectoderm and mesenchyme of the mutant buds, respectively. Engrailed-1, normally expressed in ventral limb ectoderm, is not expressed in the limbless bud. This defect precedes the normal period of AER...
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