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Article

Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud.

Development (Cambridge, England) - 1 Feb 1998

Hayes C, Brown J M, Lyon M F, Morriss-Kay G M

Abstract excerpt

The mouse mutant Doublefoot (Dbf) shows preaxial polydactyly of all four limbs. We have analysed limb development in this mutant with respect to morphogenesis, gene expression patterns and ectopic polarising activity. The results reveal a gain-of-function mutation at a locus that mediates pattern formation in the developing limb. Shh expression is identical with that of wild-type embryos, i.e. there is no ectopic...

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PMID: 9425131
DOI: 10.1242/dev.125.3.351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud.PMID 9425131Read ↗

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