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Article

The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud.

Mechanisms of development - 1 Jun 1998

Bell S M, Schreiner C M, Scott W J

Abstract excerpt

We have characterized the early stages of murine hindlimb morphogenesis in the legless (lgl)mutant and non-mutant littermates. Initially the entire ventral ectoderm expresses many genetic markers characteristic of the AER (en-1, fgf-8, msx-2, dlx-2, cd44, and cx-43). Subsequently, the expression domain of most of these genes is restricted to the thickened ectoderm of the disto-ventral limb margin prior to forming...

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PMID: 9651475
DOI: 10.1016/s0925-4773(98)00065-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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