The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud.

doi:10.1016/s0925-4773(98)00065-3

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Article

The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud.

Mechanisms of development - 1 Jun 1998

Bell S M, Schreiner C M, Scott W J

Abstract excerpt

We have characterized the early stages of murine hindlimb morphogenesis in the legless (lgl)mutant and non-mutant littermates. Initially the entire ventral ectoderm expresses many genetic markers characteristic of the AER (en-1, fgf-8, msx-2, dlx-2, cd44, and cx-43). Subsequently, the expression...

Topics

Abnormalities, Multiple
Animals
Ectoderm
Fetal Proteins
Fibroblast Growth Factor 10
Fibroblast Growth Factors
Gene Expression Regulation, Developmental
Hedgehog Proteins
Hindlimb
Homeodomain Proteins
LIM-Homeodomain Proteins
Mesoderm
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Mutant Strains
Mice, Transgenic
Morphogenesis

Source

Open in PubMed

Identifiers

PMID: 9651475
DOI: 10.1016/s0925-4773(98)00065-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9651475-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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