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Article

An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing.

Nature - 20 Jun 1996

Xu D, Nouraini S, Field D, Tang S J, Friesen J D

Abstract excerpt

The hydrolysis of ATP by a group of RNA-dependent ATPases (DEAD/H proteins) is required for spliceosome assembly, but not for the subsequent transesterification reactions. Little is known about the function of these ATPases in relation to the RNA conformational changes that occur in formation of active structures, in which U2/U6 small nuclear RNA (snRNA) interactions are essential for splicing to take place....

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Identifiers

PMID: 8649518
DOI: 10.1038/381709a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing.PMID 8649518Read ↗

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Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.Semantic proximity Read ↗

An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.Semantic proximity Read ↗

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