Article
Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts.
Development (Cambridge, England) - 1 Dec 1997
Warot X, Fromental-Ramain C, Fraulob V, Chambon P, Dollé P
Abstract excerpt
Gene targeting experiments have shown that the murine Hoxa-13 and Hoxd-13 paralogous genes control skeletal patterning in the distal region of the developing limbs. However, both genes are also expressed in the terminal part of the digestive and urogenital tracts during embryogenesis and postnata...
Topics
- Animals
- Digestive System
- Digestive System Abnormalities
- Female
- Gene Dosage
- Genitalia, Female
- Genitalia, Male
- Homeodomain Proteins
- Homozygote
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Rectum
- Transcription Factors
- Urinary Tract
- Urogenital Abnormalities
- Urogenital System