Article
[The relationship between p53 mutation and esophageal cancer biological behavior].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 10 Feb 1998
He Y, Li M, Shang X
Abstract excerpt
OBJECTIVE: To investigate the relationship between p53 mutation and esophageal cancer biological behavior as well as its prognostic role in esophageal cancer. METHOD: Mutations in exon 5-8 of p53 were screened in 30 sporadic esophageal cancers by a combination of PCR-SSCP and PCR-direct DNA silver sequencing. RESULTS: Mutations were found in 11 cases (36.7%). There were 9 point mutations, including 4 missense...
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