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Article

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.

Genes & development - 15 Oct 1996

Wang J, Takagaki Y, Manley J L

Abstract excerpt

Alternative splicing factor/splicing factor 2 (ASF/SF2) is the prototype of a family of nuclear proteins highly conserved throughout metazoa, the SR (serine/arginine) proteins. Based largely on in vitro studies, SR proteins have been suggested to play important roles in constitutive and alternati...

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Identifiers

PMID: 8895660
DOI: 10.1101/gad.10.20.2588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8895660-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.PMID 8895660Read ↗

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.Semantic proximity Read ↗

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Arginine/serine repeats are sufficient to constitute a splicing activation domain.Semantic proximity Read ↗

STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo.Semantic proximity Read ↗

Knock-in and knock-out: the use of reverse genetics in somatic cells to dissect mitotic pathways.Semantic proximity Read ↗

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