Article
Arginine/serine repeats are sufficient to constitute a splicing activation domain.
Nucleic acids research - 15 Nov 2003
Philipps Dana, Celotto Alicia M, Wang Qiao-Qiao, Tarng Rosa S, Graveley Brenton R
Abstract excerpt
SR proteins are essential pre-mRNA splicing factors that have been shown to bind a number of exonic splicing enhancers where they function to stimulate the splicing of adjacent introns. Members of the SR protein family contain one or two N-terminal RNA binding domains, as well as a C-terminal arginine-serine (RS) rich domain. The RS domains mediate protein-protein interactions with other RS domain containing...
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