Article
The second RNA-binding domain of the human splicing factor ASF/SF2 is the critical domain controlling adenovirus E1A alternative 5'-splice site selection.
The Biochemical journal - 15 Jul 2004
Dauksaite Vita, Akusjärvi Göran
Abstract excerpt
The human splicing factor ASF/SF2 (alternative splicing factor/splicing factor 2) is modular in structure with two RNA-binding domains (RBD1 and RBD2) and a C-terminal domain rich in arginine-serine dipeptide repeats. ASF/SF2 is an essential splicing factor that also functions as an important regulator of alternative splicing. In adenovirus E1A (early region 1A) alternative pre-mRNA splicing, ASF/SF2 functions as...
Topics
- Adenoviridae
- Adenovirus E1A Proteins
- Alternative Splicing
- Amino Acid Motifs
- Amino Acid Sequence
- Capsid Proteins
- Conserved Sequence
- Gene Expression Regulation, Viral
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins