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Article

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.

Cell - 12 Aug 2005

Li Xialu, Manley James L

Abstract excerpt

SR proteins constitute a family of pre-mRNA splicing factors now thought to play several roles in mRNA metabolism in metazoan cells. Here we provide evidence that a prototypical SR protein, ASF/SF2, is unexpectedly required for maintenance of genomic stability. We first show that in vivo depletion of ASF/SF2 results in a hypermutation phenotype likely due to DNA rearrangements, reflected in the rapid appearance...

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Identifiers

PMID: 16096057
DOI: 10.1016/j.cell.2005.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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