Article
Analysis of the structural requirements for lysosomal membrane targeting using transferrin receptor chimeras.
The Journal of biological chemistry - 5 Jun 1998
White S, Hatton S R, Siddiqui M A, Parker C D, Trowbridge I S, Collawn J F
Abstract excerpt
The sorting of membrane proteins to the lysosome requires tyrosine- or dileucine-based targeting signals. Recycling receptors have similar signals, yet these proteins seldom enter the latter stages of the endocytic pathway. To determine how lysosomal and internalization signals differ, we prepare...
Topics
- Acid Phosphatase
- Amino Acid Sequence
- Ammonium Chloride
- Animals
- Antigens, CD
- CD3 Complex
- Chick Embryo
- Endocytosis
- Fibroblasts
- Humans
- Immunohistochemistry
- Iron
- Lysosomal Membrane Proteins
- Lysosomes
- Membrane Glycoproteins
- Membrane Proteins
- Molecular Sequence Data
- Mutation