Article
The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi.
The Journal of cell biology - 1 Oct 1992
Johnson K F, Kornfeld S
Abstract excerpt
The mannose 6-phosphate/insulin-like growth factor-II (Man-6-P/IGF-II) receptor is known to cycle between the Golgi, endosomes, and the plasma membrane. In the Golgi the receptor binds newly synthesized lysosomal enzymes and transports them directly to an endosomal (prelysosomal) compartment with...
Topics
- Amino Acid Sequence
- Animals
- Biological Transport
- Cathepsin D
- Cell Membrane
- DNA Mutational Analysis
- Endocytosis
- Golgi Apparatus
- Insulin-Like Growth Factor II
- L Cells
- Ligands
- Lysosomes
- Mannosephosphates
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Phosphorylation