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Article

Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.

Molecular biology of the cell - 1 Jun 2001

Rohrer J, Kornfeld R

Abstract excerpt

A crucial step in lysosomal biogenesis is catalyzed by "uncovering" enzyme (UCE), which removes a covering N-acetylglucosamine from the mannose 6-phosphate (Man-6-P) recognition marker on lysosomal hydrolases. This study shows that UCE resides in the trans-Golgi network (TGN) and cycles between the TGN and plasma membrane. The cytosolic domain of UCE contains two potential endocytosis motifs: (488)YHPL and...

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Identifiers

PMID: 11408573
DOI: 10.1091/mbc.12.6.1623
PMCID: PMC37329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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