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Article

Mutation variants generated from nonvirulent coxsackievirus B3 acquire virulence phenotypes by active virus replication.

Intervirology - 1 Jan 2007

Seo Ilseon, Jee Youngmee, Ahn Jeonghyun, Jun Eun Jung, Kim Donghou, Joo Chul Hyun, Kim Yoo Kyum, Lee Heuiran

Abstract excerpt

OBJECTIVE: To understand coxsackievirus B3 (CVB3) virulence at the molecular level. METHOD: A mutation library was generated from noncardiovirulent CVB3/0. Highly virulent mutation variants were recovered and characterized both phenotypically and genotypically. RESULTS: The variants consistently caused destruction of multiple tissues together with active virus production and induced severe mortality in vivo. The...

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PMID: 18268408
DOI: 10.1159/000115950

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