Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An attenuated variant of Coxsackievirus B3 preferentially induces immunoregulatory T cells in vivo.

Journal of virology - 1 Nov 1991

Loudon R P, Moraska A F, Huber S A, Schwimmbeck P, Schultheiss P

Abstract excerpt

BALB/c mice infected with the Woodruff variant of coxsackievirus group B type 3 (CVB3W) develop myocarditis mediated by autoimmune cytolytic T lymphocytes. A variant of CVB3W (designated H3-10A1) which infects the myocardium but induces minimal mortality of myocarditis compared to the parental virus was selected. Although H3-10A1 infections stimulate normal CTL responses to CVB3-infected myocytes, the autoimmune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to CD4 Antigens
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Mice, Inbred BALB C

Share to Spleen

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 1656071
DOI: 10.1128/JVI.65.11.5813-5819.1991
PMCID: PMC250243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An attenuated variant of Coxsackievirus B3 preferentially induces immunoregulatory T cells in vivo.PMID 1656071Read ↗

A non-cardiovirulent strain of coxsackievirus B3 causes myocarditis in mice with severe combined immunodeficiency syndrome.Semantic proximity Read ↗

Selection of an attenuated Coxsackievirus B3 variant, using a monoclonal antibody reactive to myocyte antigen.Semantic proximity Read ↗

Role of CD1d in coxsackievirus B3-induced myocarditis.Semantic proximity Read ↗

A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3.Semantic proximity Read ↗

V gamma 1+ T cells suppress and V gamma 4+ T cells promote susceptibility to coxsackievirus B3-induced myocarditis in mice.Semantic proximity Read ↗

Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis.Semantic proximity Read ↗

Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditis.Semantic proximity Read ↗

T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity.Semantic proximity Read ↗

Differential effects of myocarditic variants of Coxsackievirus B3 in inbred mice. A pathologic characterization of heart tissue damage.Semantic proximity Read ↗

Mutations in the 5' NTR and the Non-Structural Protein 3A of the Coxsackievirus B3 Selectively Attenuate Myocarditogenicity.Semantic proximity Read ↗

Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype.Semantic proximity Read ↗

Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.