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Article

Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis.

Scientific reports - 14 Jun 2021

Lasrado Ninaad, Gangaplara Arunakumar, Massilamany Chandirasegaran, Arumugam Rajkumar, Shelbourn Allison, Rasquinha Mahima T, Basavalingappa Rakesh H, Delhon Gustavo, Xiang Shi-Hua, Pattnaik Asit K, Steffen David, Reddy Jay

Abstract excerpt

Coxsackievirus B3 (CVB3), is commonly implicated in myocarditis, which can lead to dilated cardiomyopathy, in addition to causing acute pancreatitis and meningitis. Yet, no vaccines are currently available to prevent this infection. Here, we describe the derivation of a live attenuated vaccine virus, termed mutant (Mt) 10, encoding a single amino acid substitution H790A within the viral protein 1, that prevents...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enterovirus B, Human

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Source

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Identifiers

PMID: 34127684
DOI: 10.1038/s41598-021-90434-w
PMCID: PMC8203608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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