Article
Hypomutable potential accompanying interferon-alpha resistance in a human cell line, IFr, derived from interferon-alpha-sensitive and hypermutable RSa cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Sept 1996
Suzuki N, Suzuki H, Ishizuka T, Yamamori H, Takakubo Y
Abstract excerpt
A human cell line, IFr, established from RSa cells, is a variant with increased resistance to cell proliferation inhibition (CPI) by human interferon (HuIFN)-alpha. The parent RSa cells are also hypermutable after irradiation with far-ultraviolet light (UV), as assessed by two different methods:...
Topics
- Antipain
- Antiviral Agents
- Cell Division
- Cell Line
- Codon
- Drug Resistance
- Genes, ras
- Genome, Human
- Humans
- Interferon-alpha
- Mutagenicity Tests
- Ouabain
- Phenotype
- Protease Inhibitors
- Ultraviolet Rays