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Article

Protease activation following UV irradiation is linked to hypomutability in human cells selected for resistance to combination of UV and antipain.

Mutation research - 17 Jul 1998

Isogai E, Ishijima S, Sonoda T, Kita K, Suzuki H, Hasegawa R, Yamamori H, Takakubo Y, Suzuki N

Abstract excerpt

In order to examine the relationship between activation of an antipain-sensitive protease and suppression of mutability in UV (UVC)-irradiated human cells, a human cell variant with the high protease activity induced by UV was established and characterized for its susceptibility to UV-induced mutagenicity. Cells of a hypermutable cell strain, RSa, were mutagenized with ethyl methanesulfonate and irradiated with...

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Identifiers

PMID: 9726021
DOI: 10.1016/s0027-5107(98)00081-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protease activation following UV irradiation is linked to hypomutability in human cells selected for resistance to combination of UV and antipain.PMID 9726021Read ↗

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Human cell clones, RSa and UVr-1, differing in their capability for UV-induced virus reactivation and phenotypic mutation.Semantic proximity Read ↗

The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit.Semantic proximity Read ↗

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UV-induced mutations affecting codon 12 of the K-ras gene are suppressed by interferon-alpha in human RSa cells.Semantic proximity Read ↗

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