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Article

Protease activation following UV irradiation is linked to hypomutability in human cells selected for resistance to combination of UV and antipain.

Mutation research - 17 Jul 1998

Isogai E, Ishijima S, Sonoda T, Kita K, Suzuki H, Hasegawa R, Yamamori H, Takakubo Y, Suzuki N

Abstract excerpt

In order to examine the relationship between activation of an antipain-sensitive protease and suppression of mutability in UV (UVC)-irradiated human cells, a human cell variant with the high protease activity induced by UV was established and characterized for its susceptibility to UV-induced mut...

Topics

Antipain
Cell Line
Cell Survival
Codon
Drug Resistance
Endopeptidases
Genes, ras
Genetic Variation
Humans
Mutation
Ouabain
Protease Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Radiation Tolerance

Ultraviolet Rays

Source

Identifiers

PMID: 9726021
DOI: 10.1016/s0027-5107(98)00081-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9726021-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Protease activation following UV irradiation is linked to hypomutability in human cells selected for resistance to combination of UV and antipain.PMID 9726021Read ↗

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