Article
Increased levels of UV-induced protease activity in human UVAP-1 cells exposed to gravity-changing stress: involvement of E-64-sensitive proteases in suppression of UV mutagenicity.
Cell biology international - 1 Jan 2003
Takahashi Shunji, Zhang Hong-Chang, Hasegawa Ritsuko, Karata Kiyonobu, Kita Kazuko, Wano Chieko, Yamaguchi Yoshitaka, Sugaya Shigeru, Nomura Jun, Ichinose Masaharu, Suzuki Nobuo
Abstract excerpt
Under the 1G condition, the increase in antipain-sensitive protease activity promptly after UV (mainly 254 nm wavelength) irradiation in cultured human cells is detected and found to be one of the intriguing events involved in suppression of cell mutability. It was found that two cell lines, RSa and its variant UVAP-1 cells are applicable; the former is hypermutable and not susceptible to protease activation,...
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