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Article

Epigenetic silencing of interferon-inducible genes is implicated in interferon resistance of hepatitis C virus replicon-harboring cells.

Journal of hepatology - 1 May 2006

Naka Kazuhito, Abe Ken-ichi, Takemoto Kazunori, Dansako Hiromichi, Ikeda Masanori, Shimotohno Kunitada, Kato Nobuyuki

Abstract excerpt

BACKGROUND/AIMS: We previously established hepatitis C virus (HCV) replicon-harboring cell lines possessing two interferon (IFN)-resistant phenotypes: a partially resistant phenotype (alphaR series) and a severely resistant phenotype (betaR series). We recently found that the severe IFN resistance of the betaR-series cells is caused by the functional disruption of type I IFN receptors. Here, we aimed to clarify...

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Identifiers

PMID: 16545484
DOI: 10.1016/j.jhep.2006.01.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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