Article
UV-induced mutations affecting codon 12 of the K-ras gene are suppressed by interferon-alpha in human RSa cells.
Mutation research - 3 Feb 1997
Suzuki N, Suzuki H, Ishizuka T, Yamamori H, Ino H
Abstract excerpt
K-ras gene sequences mutant at codon 12 were recovered following differential dot-blot hybridization of genomic DNA from human RSa cells up to 12 days after the cells had been irradiated with far-UV (principally 254 nm). By contrast, no mutant codon 12 sequences were recovered from cells which had been treated with 50 IU/ml human interferon (HuIFN)-alpha for 24 h prior to their UV exposure. HuIFN-alpha treatment...
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