Detection of serum factors enhancing cell mutability from lung cancer patients by application of hypermutable human RS cells.

doi:10.1002/(sici)1097-0215(19981123)78:5<550::aid-ijc4>3.0.co;2-0

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Article

Detection of serum factors enhancing cell mutability from lung cancer patients by application of hypermutable human RS cells.

International journal of cancer - 23 Nov 1998

Suzuki N, Ishibashi M, Kita K, Wu Y P, Nomura J, Takakubo Y, Hiroshima K, Genga K, Ohwada H, Hayashi Y

Abstract excerpt

A search for serum factors that modulate the mutability of human cells has been attempted in the peripheral blood of lung cancer patients. Factors were separated by dye-ligand chromatography and first identified as those exhibiting the ability to enhance the frequency of drug-resistance mutations in human RSa cells. The frequency was assessed by estimation of the cloning efficiency of mutant cells resistant to...

Topics

Adult
Aged
Codon
Female
Genes, ras
Humans
Interferon-beta
Lung Neoplasms
Male
Middle Aged
Mutation
Ouabain
Ultraviolet Rays

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Identifiers

PMID: 9808521
DOI: 10.1002/(sici)1097-0215(19981123)78:5<550::aid-ijc4>3.0.co;2-0

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