Article
Detection of serum factors enhancing cell mutability from lung cancer patients by application of hypermutable human RS cells.
International journal of cancer - 23 Nov 1998
Suzuki N, Ishibashi M, Kita K, Wu Y P, Nomura J, Takakubo Y, Hiroshima K, Genga K, Ohwada H, Hayashi Y
Abstract excerpt
A search for serum factors that modulate the mutability of human cells has been attempted in the peripheral blood of lung cancer patients. Factors were separated by dye-ligand chromatography and first identified as those exhibiting the ability to enhance the frequency of drug-resistance mutations in human RSa cells. The frequency was assessed by estimation of the cloning efficiency of mutant cells resistant to...
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