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Article

Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-alpha.

Blood - 1 Jun 1994

Li Y P, Said F, Gallagher R E

Abstract excerpt

Sequence analysis of the retinoic acid receptor-alpha (RAR alpha) gene from a subline of HL-60 cells (RA-res) stably resistant to all-trans retinoic acid (RA) disclosed a single-base change in codon number 411, the same C to T transition previously reported in an independently selected HL-60 RA resistant clone by Robertson et al (Blood 80:1885, 1992). This mutation eliminates a FokI restriction endonuclease site....

Topics

Alleles
Base Sequence
Blotting, Southern
Drug Resistance
Humans
Leukemia, Promyelocytic, Acute
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Receptors, Retinoic Acid
Tretinoin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 8193365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8193365-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-alpha.PMID 8193365Read ↗

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