Article
A novel short L-arginine responsive protein-coding gene (laoB) antiparallel overlapping to a CadC-like transcriptional regulator in Escherichia coli O157:H7 Sakai originated by overprinting.
BMC evolutionary biology - 12 Feb 2018
Hücker Sarah M, Vanderhaeghen Sonja, Abellan-Schneyder Isabel, Wecko Romy, Simon Svenja, Scherer Siegfried, Neuhaus Klaus
Abstract excerpt
BACKGROUND: Due to the DNA triplet code, it is possible that the sequences of two or more protein-coding genes overlap to a large degree. However, such non-trivial overlaps are usually excluded by genome annotation pipelines and, thus, only a few overlapping gene pairs have been described in bacteria. In contrast, transcriptome and translatome sequencing reveals many signals originated from the antisense strand...
Topics
- Arginine
- Base Sequence
- Escherichia coli O157
- Escherichia coli Proteins
- Genes, Bacterial
- Genes, Overlapping
- Green Fluorescent Proteins
- Mutation
- Open Reading Frames
- Phylogeny
- Promoter Regions, Genetic
- Protein Biosynthesis