Article
Mechanism of post-segregational killing by the hok/sok system of plasmid R1. Sok antisense RNA regulates hok gene expression indirectly through the overlapping mok gene.
Journal of molecular biology - 5 Jan 1992
Thisted T, Gerdes K
Abstract excerpt
The hok/sok locus of plasmid R1, which mediates plasmid stabilization by killing of plasmid-free segregants, codes for two RNAs, Hok mRNA and Sok antisense RNA. Hok mRNA encodes the Hok killer protein of 52 amino acid residues. Expression of hok is regulated post-transcriptionally by Sok antisense RNA. Killing of plasmid-free daughter-cells by the hok/sok system is accomplished through differential decay of the...
Topics
- Base Sequence
- Cell Division
- DNA, Bacterial
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Molecular Sequence Data
- Phenotype
- Plasmids
- Protein Biosynthesis
- RNA, Antisense