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Article

RNase R degrades non-stop mRNAs selectively in an SmpB-tmRNA-dependent manner.

Molecular microbiology - 1 Dec 2006

Richards Jamie, Mehta Preeti, Karzai A Wall

Abstract excerpt

The SmpB-tmRNA-mediated trans-translation system has two well-established activities: rescuing ribosomes stalled on aberrant mRNAs and marking the associated protein fragments for proteolysis. Although the causative non-stop mRNAs are known to be degraded, little is known about the enabling mechanism or the RNases involved in their disposal. We report that Escherichia coli has an enabling mechanism that requires...

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PMID: 17087776
DOI: 10.1111/j.1365-2958.2006.05472.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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