Article
An antisense/target RNA duplex or a strong intramolecular RNA structure 5' of a translation initiation signal blocks ribosome binding: the case of plasmid R1.
RNA (New York, N.Y.) - 1 Oct 1996
Malmgren C, Engdahl H M, Romby P, Wagner E G
Abstract excerpt
Antisense RNAs in prokaryotic systems often inhibit translation of mRNAs. In some cases, this involves sequestration of Shine-Dalgarno (SD) sequences and start codons. In other cases, antisense/target RNA duplexes do not overlap these signals, but form upstream. We have performed toeprinting anal...
Topics
- Bacterial Proteins
- Base Sequence
- DNA Helicases
- DNA-Binding Proteins
- Escherichia coli
- Genetic Techniques
- Kinetics
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Peptide Chain Initiation, Translational
- Protein Sorting Signals
- Proteins
- R Factors
- RNA, Antisense
- RNA, Bacterial
- RNA, Messenger
- Ribosomes