Mechanism of post-segregational killing by hok-homologue pnd of plasmid R483: two translational control elements in the pnd mRNA.

doi:10.1006/jmbi.1995.0296

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Article

Mechanism of post-segregational killing by hok-homologue pnd of plasmid R483: two translational control elements in the pnd mRNA.

Journal of molecular biology - 2 Jun 1995

Nielsen A K, Gerdes K

Abstract excerpt

The pnd system of plasmid R483 mediates plasmid stabilization by killing of plasmid-free cells. The pnd mRNA is very stable and can be translated into PndA protein, a cell toxin which kills the cells from within by damaging the cell membrane. Translation of the pnd mRNA is inhibited by the PndB antisense, a small labile RNA of 63 nt. The rapid decay of the PndB antidote leads to onset of PndA synthesis in...

Topics

Bacterial Proteins
Bacterial Toxins
Base Sequence
Blotting, Northern
DNA Primers
Escherichia coli
Escherichia coli Proteins
Genotype
Models, Genetic
Molecular Sequence Data
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Plasmids

Polymerase Chain Reaction

Protein Biosynthesis

RNA, Messenger

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 7783193
DOI: 10.1006/jmbi.1995.0296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7783193-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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