Article
Translational activation by the noncoding RNA DsrA involves alternative RNase III processing in the rpoS 5'-leader.
RNA (New York, N.Y.) - 1 Mar 2008
Resch Armin, Afonyushkin Taras, Lombo Tania B, McDowall Kenneth J, Bläsi Udo, Kaberdin Vladimir R
Abstract excerpt
The intricate regulation of the Escherichia coli rpoS gene, which encodes the stationary phase sigma-factor sigmaS, includes translational activation by the noncoding RNA DsrA. We observed that the stability of rpoS mRNA, and concomitantly the concentration of sigmaS, were significantly higher in an RNase III-deficient mutant. As no decay intermediates corresponding to the in vitro mapped RNase III cleavage site...
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