Article
Mutations of E2F-4 trinucleotide repeats in colorectal cancer with microsatellite instability.
Biochemical and biophysical research communications - 14 Oct 1996
Yoshitaka T, Matsubara N, Ikeda M, Tanino M, Hanafusa H, Tanaka N, Shimizu K
Abstract excerpt
Genetic instability at microsatellites in some colorectal cancer (CRC) have been linked to the defects of human mismatch repair genes, but the targets of these defective genes have been largely unknown. We screened CRC specimens for alteration of E2F-4 gene by analyzing both cDNA and genomic sequences along with replication error (RER+) phenotype. Two out of 20 sporadic CRC patients showed RER+ phenotype. We...
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