Article
Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas.
Human mutation - 1 Jan 1997
Yin J, Kong D, Wang S, Zou T T, Souza R F, Smolinski K N, Lynch P M, Hamilton S R, Sugimura H, Powell S M, Young J, Abraham J M, Meltzer S J
Abstract excerpt
Mutations within microsatellite sequences, consisting of additions or deletions of repeat units, are known as the replication/repair error positive (RER+) phenotype or micorsatellite instability (MI). Microsatellite instability has been demonstrated in hereditary and sporadic colorectal carcinoma...
Topics
- Adenocarcinoma
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Mutational Analysis
- DNA Repair
- DNA-Binding Proteins
- Frameshift Mutation
- Genes, Neoplasm
- Humans
- Microsatellite Repeats
- Multidrug Resistance-Associated Proteins
- MutS Homolog 3 Protein
- Phenotype