Article
Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas.
Human mutation - 1 Jan 1997
Yin J, Kong D, Wang S, Zou T T, Souza R F, Smolinski K N, Lynch P M, Hamilton S R, Sugimura H, Powell S M, Young J, Abraham J M, Meltzer S J
Abstract excerpt
Mutations within microsatellite sequences, consisting of additions or deletions of repeat units, are known as the replication/repair error positive (RER+) phenotype or micorsatellite instability (MI). Microsatellite instability has been demonstrated in hereditary and sporadic colorectal carcinomas and is usually observed in noncoding regions of genomic DNA. However, relatively few coding region targets of MI have...
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