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Article

Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites.

Genes, chromosomes & cancer - 1 Feb 1998

Zhou X P, Hoang J M, Li Y J, Seruca R, Carneiro F, Sobrinho-Simoes M, Lothe R A, Gleeson C M, Russell S E, Muzeau F, Fléjou J F, Hoang-Xuan K, Lidereau R, Thomas G, Hamelin R

Abstract excerpt

Microsatellite instability (MI) characterizing tumors with replication errors (RER+ tumors) was first described in colorectal tumors from hereditary non-polyposis colorectal cancer (HNPCC) patients as well as in sporadic cases. It has also been observed in subgroups of extracolonic sporadic tumors, but there is no consensus as to the number of microsatellite loci to examine, and the threshold percentage of...

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Identifiers

PMID: 9491320
DOI: 10.1002/(sici)1098-2264(199802)21:2<101::aid-gcc4>3.0.co;2-4

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