Article
Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites.
Genes, chromosomes & cancer - 1 Feb 1998
Zhou X P, Hoang J M, Li Y J, Seruca R, Carneiro F, Sobrinho-Simoes M, Lothe R A, Gleeson C M, Russell S E, Muzeau F, Fléjou J F, Hoang-Xuan K, Lidereau R, Thomas G, Hamelin R
Abstract excerpt
Microsatellite instability (MI) characterizing tumors with replication errors (RER+ tumors) was first described in colorectal tumors from hereditary non-polyposis colorectal cancer (HNPCC) patients as well as in sporadic cases. It has also been observed in subgroups of extracolonic sporadic tumor...
Topics
- Breast Neoplasms
- Colorectal Neoplasms
- DNA Repair
- DNA Replication
- Endometrial Neoplasms
- Esophageal Neoplasms
- Female
- Glioma
- Humans
- Male
- Microsatellite Repeats
- Neoplasms
- Phenotype
- Prostatic Neoplasms