Article
Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma.
The American journal of pathology - 1 May 1996
Caduff R F, Johnston C M, Svoboda-Newman S M, Poy E L, Merajver S D, Frank T S
Abstract excerpt
Defective DNA mismatch repair in neoplasia is manifested by extra, aberrant bands within multiple microsatellite markers. The replication error (RER) phenotype is present in most colorectal and endometrial carcinomas in patients with the hereditary nonpolyposis colorectal carcinoma syndrome. In a...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- DNA Primers
- DNA, Neoplasm
- Endometrial Neoplasms
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genes, ras
- Genotype
- Humans
- Immunohistochemistry
- Microsatellite Repeats
- Middle Aged
- Molecular Sequence Data
- Mutation