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Article

E2F-4 mutation in hereditary non-polyposis colorectal cancer.

Journal of experimental & clinical cancer research : CR - 1 Jun 2002

Moriyama H, Sasamoto H, Kambara T, Matsubara N, Ikeda M, Baba S, Meltzer S J, Lynch H T, Shimizu K, Tanaka N

Abstract excerpt

Defects in the DNA mismatch repair function are known to cause microsatellite instability (MSI) in hereditary non-polyposis colorectal cancer (HNPCC) as well as in a subset of sporadic colorectal cancer (CRC). We previously reported that the E2F-4 gene, which encodes an important transcription factor in cell cycle control, had frequent tumor-specific mutations at a coding region of trinucleotide microsatellite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Share to Proto-Oncogene Proteins c-bcl-2

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PMID: 12148576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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