Article
Microsatellite instability in primary and metastatic colorectal cancers.
International journal of cancer - 22 Jun 1995
Ishimaru G, Adachi J, Shiseki M, Yamaguchi N, Muto T, Yokota J
Abstract excerpt
Microsatellite instability characterizes a sub-set of sporadic colorectal cancers (CRCs) as well as CRCs from patients with hereditary non-polyposis colorectal cancer (HNPCC). In order to clarify when the cells acquire a replication-error phenotype (RER) during colorectal-tumor progression, we examined the incidence of RER in 80 primary tumors and 36 liver metastases at 8 microsatellite loci; 1 mono-, 5 di-, 1...
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