Article
Effect of in vivo rapamycin treatment on de novo T-cell development in relation to induction of autoimmune-like immunopathology in the rat.
Transplantation - 15 Oct 1996
Damoiseaux J G, Beijleveld L J, Schuurman H J, van Breda Vriesman P J
Abstract excerpt
Cyclosporine (CsA) and FK506 are structurally unrelated immunosuppressants, but function in similar ways. FK506 and rapamycin (RAPA), on the other hand, have structural similarities, but act by different mechanisms to yield immunosuppression. Besides their immunosuppressive action, CsA and FK506...
Topics
- Animals
- Autoimmune Diseases
- Autoimmunity
- Disease Susceptibility
- Female
- Flow Cytometry
- Immunosuppressive Agents
- Phenotype
- Polyenes
- Rats
- Rats, Inbred BN
- Rats, Inbred Lew
- Sirolimus
- T-Lymphocyte Subsets
- T-Lymphocytes
- Th1 Cells
- Th2 Cells
- Thymus Gland