Article
Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.
The Journal of experimental medicine - 1 Mar 1993
Fowell D, Mason D
Abstract excerpt
Diabetes was induced in a normal nonautoimmune rat strain by rendering the animals relatively T cell deficient using a protocol of adult thymectomy and sublethal gamma irradiation. All male rats and 70% of females developed an acute syndrome with severe loss of weight and hyperglycemia. Diabetes...
Topics
- Animals
- Autoimmune Diseases
- Autoimmunity
- CD4-Positive T-Lymphocytes
- CD8 Antigens
- Diabetes Mellitus, Experimental
- Female
- Flow Cytometry
- Immunohistochemistry
- Interleukin-10
- Interleukin-2
- Interleukin-4
- Leukocyte Common Antigens
- Lymphocyte Depletion
- Macrophages
- Male
- Phenotype
- Rats