Article
The lesions of cyclosporine-induced autoimmune disease can be equally well elicited by CD4 or CD8 effector T cells.
Transplantation - 27 Nov 1996
Beijleveld L J, Damoiseaux J G, Roglic M, Theofilopoulos A N, van Breda Vriesman P J
Abstract excerpt
Lethally irradiated Lewis rats reconstituted with syngeneic bone marrow and given cyclosporine for 4 weeks develop a graft-versus-host-like disease upon withdrawal of CsA. Autoreactive T cells inducing this thymus-dependent autoimmune disease, termed CsA-AI, are demonstrable by adoptive transfer,...
Topics
- Adoptive Transfer
- Animals
- Autoimmune Diseases
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Separation
- Cyclosporine
- Female
- Flow Cytometry
- Graft vs Host Disease
- Histocompatibility Antigens Class II
- Immunoglobulin Variable Region
- Keratinocytes
- Lymphocyte Subsets
- Phenotype
- Rats
- Rats, Inbred Lew
- Receptors, Antigen, T-Cell, alpha-beta