T-cell maturation and clonal deletion in cyclosporine-induced autoimmunity.

doi:10.1016/0896-8411(91)90030-g

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Article

T-cell maturation and clonal deletion in cyclosporine-induced autoimmunity.

Journal of autoimmunity - 1 Apr 1991

Prud'homme G J, Sanders R, Parfrey N A, Ste-Croix H

Abstract excerpt

In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, on...

Topics

Animals
Autoimmune Diseases
Bone Marrow Transplantation
Cell Differentiation
Clone Cells
Cyclosporins
Disease Susceptibility
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genetic Predisposition to Disease
Graft vs Host Disease
Mice
Mice, Inbred DBA
Mice, Inbred Strains
Radiation Chimera
Rats
Rats, Inbred Strains
Species Specificity
T-Lymphocyte Subsets

Source

Open in PubMed

Identifiers

PMID: 1652970
DOI: 10.1016/0896-8411(91)90030-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1652970-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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