Article
Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells.
Transplantation - 1 Sept 2015
Gallon Lorenzo, Traitanon Opas, Yu Yuming, Shi Bo, Leventhal Joseph R, Miller Joshua, Mas Valeria, L Xu, Mathew James M
Abstract excerpt
BACKGROUND: Previously, we had reported the role of tacrolimus (TAC) versus sirolimus (SRL) on the generation of regulatory T cells (Tregs) in primary MLR assays with SRL, demonstrating a uniquely supportive effect. However, the mechanisms associated with their actions on alloreactive human T cells are not fully understood. Therefore, we tested whether TAC and SRL differentially affect already alloactivated human...
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