Article
Abrogation by rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and endothelial cell activation, cytokine production, and cell adhesion.
Transplantation - 27 Mar 1994
Schmidbauer G, Hancock W W, Wasowska B, Badger A M, Kupiec-Weglinski J W
Abstract excerpt
This study evaluated the efficacy and mode of action of rapamycin (RPM) in a model of accelerated (24-hr) rejection of LBNF1 cardiac allografts in specifically sensitized LEW rats. RPM treatment (0.25 mg/kg/day i.p.) between the day of sensitizing skin grafts (day -7) and subsequent heart (day 0) transplantation (Tx), abrogated fulminant rejection and prolonged cardiac allograft survival to 46 +/- 22 days (mean...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Adhesion
- Cytokines
- Endothelium
- Graft Rejection
- Graft Survival
- Heart Transplantation
- Immunoglobulin G
- Immunoglobulin M