Article
Rapamycin prevents bronchiolitis obliterans through increasing infiltration of regulatory B cells in a murine tracheal transplantation model.
The Journal of thoracic and cardiovascular surgery - 1 Feb 2016
Zhao Yunge, Gillen Jacob R, Meher Akshaya K, Burns Jordan A, Kron Irving L, Lau Christine L
Abstract excerpt
OBJECTIVE: B lymphocytes are generally considered to be activators of the immune response; however, recent findings have shown that a subtype of B lymphocytes, regulatory B lymphocytes, play a role in attenuating the immune response. Bronchiolitis obliterans remains the major limitation to modern-day lung transplantation. The role of regulatory B lymphocytes in bronchiolitis obliterans has not been elucidated. We...
Topics
- Animals
- Anti-Inflammatory Agents
- B-Lymphocytes
- Bronchiolitis Obliterans
- Chemotaxis, Leukocyte
- Cytokines
- Disease Models, Animal
- Inflammation Mediators
- Male
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Phenotype
- Sirolimus