Article
Signs of immaturity of splenic dendritic cells from the autoimmune prone biobreeding rat: consequences for the in vitro expansion of regulator and effector T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999
Delemarre F G, Simons P J, de Heer H J, Drexhage H A
Abstract excerpt
From the biobreeding-diabetic prone (BB-DP) rat, an animal model for endocrine autoimmunity, phenotype and function of splenic dendritic cells (DC) were studied. Furthermore, the suppressive effect of peritoneal macrophages (pMphi) from the BB-DP rat in the MLR was investigated. Lower numbers of...
Topics
- Animals
- Autoimmune Diseases
- Cell Differentiation
- Dendritic Cells
- Dextrans
- Diabetes Mellitus, Type 1
- Escherichia coli
- Female
- Fluorescein-5-isothiocyanate
- Histocompatibility Antigens Class II
- In Vitro Techniques
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed
- Macrophages, Peritoneal
- Male
- Phagocytosis
- Phenotype
- Rats