Article
Mismatch repair defects in human carcinogenesis.
Human molecular genetics - 1 Jan 1996
Eshleman J R, Markowitz S D
Abstract excerpt
Mismatch repair defects are carcinogenic. This conclusion comes some 80 years after the original description of a type of familial colorectal cancer in which mismatch repair defects are involved, and from decades of dedicated basic science research into fundamental mechanisms cells use to repair their DNA. Mismatch repair (MMR) was described first in bacteria, later in yeast and finally in higher eukaryotes. In...
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