Article
Mismatch repair defects in human carcinogenesis.
Human molecular genetics - 1 Jan 1996
Eshleman J R, Markowitz S D
Abstract excerpt
Mismatch repair defects are carcinogenic. This conclusion comes some 80 years after the original description of a type of familial colorectal cancer in which mismatch repair defects are involved, and from decades of dedicated basic science research into fundamental mechanisms cells use to repair...
Topics
- Animals
- Bacteria
- Carcinogenicity Tests
- DNA Repair
- DNA Replication
- DNA, Neoplasm
- Humans
- Microsatellite Repeats
- Mutation
- Neoplasms
- Phenotype