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Article

Mechanisms in Eukaryotic Mismatch Repair

11 Aug 2006

Abstract excerpt

Inactivation of the human mismatch repair system confers a large increase in spontaneous mutability and a strong predisposition to tumor development. Mismatch repair provides several genetic stabilization functions; it corrects DNA biosynthetic errors, ensures the fidelity of genetic recombination, and participates in the earliest steps of checkpoint and apoptotic responses to several classes of DNA damage (see...

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PMID: 16905530
DOI: 10.1074/jbc.r600022200

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