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DNA mismatch repair-dependent DNA damage responses and cancer

1 Sept 2020

Abstract excerpt

Canonical DNA mismatch repair (MMR) excises base-base mismatches to increase the fidelity of DNA replication. Thus, loss of MMR leads to increased spontaneous mutagenesis. MMR genes also are involved in the suppression of mutagenic, and the induction of protective, responses to various types of DNA damage. In this review we describe these non-canonical roles of MMR at different lesion types. Loss of non-canonical...

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PMID: 33087264
DOI: 10.1016/j.dnarep.2020.102923

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